A Change in Hemoglobins Structure Can Disturb Hemoglobin Function Essa

A Change in hemoglobins Structure Can press haemoglobin FunctionAbstractThe fact that a molecule?s organize determines its wreak can be seen throughthe oxygen car transporter protein, hemoglobin. hemoglobin can riposte two forms, oxy stateand deoxy state, and each performs a different flow for the hemoglobin. In a mean(prenominal)hemoglobin, the oxygen binds to a haemitin group during the oxy state and releases oxygenduring the deoxy state. However, when hemoglobin is mutated ex kindable in reap hook cadre anemia,in which the amino acid glumatic acid is substituted with valine in the 6th position ofbeta subunit the hemoglobin will non function correctly in the deoxy state. This will leadthe hemoglobin to take a reaping hook shape that will eventually cause sickle mobile phone anemia.Imagine doing an internship in the emergency department of the hospital,suddenly, a cardinal socio-economic class old athlete comes to the ER that is having hard time breathing. Theresult s from the tests that were do on the athlete show that he could not become like hisidol, Michel Jordan, in basketball because he has sickle cell anemia. During the talk with bingle of the doctors that you were working with, you discover that sickle cell anemia is a hereditary illness that occurs due to the deficiency of the red blood cells. This is causedby a hereditary mutation in the hemoglobin, an oxygen carrier protein, in which i aminoacid is changed to another. This mutation in the structure of the hemoglobin disturbs theproteins? normal function and eventually leads to sickle cell anemia. Have you wonderedhow this small change in the structure of hemoglobin can cause sickle cell anemia, and3stop the athlete from playing basketball? Well, this is one of the important topics that w... ...6um%3D1%26hl%3Den.(3)blood hemoglobin tetramer. Encyclopedia Britannica. 2007. EncyclopdiaBritannica, Inc. . 27 Jul 2008.(4) Porphyrin. The secrete Dictionary. procure 2008 . Farlex, Inc.. 27 Jul 2008.(5)DR.JAKUBOWSKI,CHAPTER5-BINDING.05/16/08.27Jul2008html.6)Voet, Donald. Biochemsitry . 1990. John Wiely ,7, 8) ?How Does Sickle Cell aim sickness?. April 11, 2002 . harvard . 27 Jul 2008.12AcknowledgmentsI acknowledge Dr. Peck, Mike, Bless and my professors from the alchemy crowdDean, Tim, and Tobey for always being there for me whenever I needed their protagonist to lighter this project. A Change in Hemoglobins Structure Can Disturb Hemoglobin Function EssaA Change in Hemoglobins Structure Can Disturb Hemoglobin FunctionAbstractThe fact that a molecule?s structure determines its function can be seen throughthe oxygen transporter protein, hemoglobin. Hemoglobin can take two forms, oxy stateand deoxy state, and each performs a distinct function for the hemoglobin. In a normalhemoglobin, the oxygen binds to a heme group during the oxy state and releases oxygenduring the deoxy state. However, when hemoglobin is mutated like in sickle cell anemia,i n which the amino acid glumatic acid is substituted with valine in the sixth position ofbeta subunit the hemoglobin will not function correctly in the deoxy state. This will leadthe hemoglobin to take a sickle shape that will eventually cause sickle cell anemia.Imagine doing an internship in the emergency department of the hospital,suddenly, a five year old athlete comes to the ER that is having hard time breathing. Theresults from the tests that were done on the athlete show that he could not become like hisidol, Michel Jordan, in basketball because he has sickle cell anemia. During the talk withone of the doctors that you were working with, you discover that sickle cell anemia is ahereditary disease that occurs due to the deficiency of the red blood cells. This is causedby a genetic mutation in the hemoglobin, an oxygen carrier protein, in which one aminoacid is changed to another. This mutation in the structure of the hemoglobin disturbs theproteins? normal function and eventuall y leads to sickle cell anemia. Have you wonderedhow this small change in the structure of hemoglobin can cause sickle cell anemia, and3stop the athlete from playing basketball? Well, this is one of the main topics that w... ...6um%3D1%26hl%3Den.(3)blood hemoglobin tetramer. Encyclopedia Britannica. 2007. EncyclopdiaBritannica, Inc. . 27 Jul 2008.(4) Porphyrin. The Free Dictionary. Copyright 2008 . Farlex, Inc.. 27 Jul 2008.(5)DR.JAKUBOWSKI,CHAPTER5-BINDING.05/16/08.27Jul2008html.6)Voet, Donald. Biochemsitry . 1990. John Wiely ,7, 8) ?How Does Sickle Cell Cause Disease?. April 11, 2002 . harvard . 27 Jul 2008.12AcknowledgmentsI acknowledge Dr. Peck, Mike, Bless and my professors from the chemistry clusterDean, Tim, and Tobey for always being there for me whenever I needed their help tospark this project.